President Joe Biden and the first lady delivered remarks at a commissioning commemoration ceremony of the USS Delaware on Saturday.
At the event in Wilmington, Biden said the nuclear-powered submarine would enhance national security.
"I believe it is our sacred obligation as nation to prepare and equip those troops that we send into harm’s way and to care for them and their families when they return home," Biden told the audience.
Saturday marked the president's first visit to his home state in several weeks, USA Today reported.
The 377-foot-long vessel marks the first time for a Navy vessel to bear the state’s name in nearly a century.
According to the US Navy archives, the nuclear-powered submarine is the seventh submarine named after the state, with the first being in 1776.