Accumulations are expected to be modest but a winter weather advisory is posted for areas that include central and northeast Oklahoma.
Authorities are also advising not to travel in Tulsa, Creek, Okmulgee and Rogers counties.
The National Weather Service said Saturday that wintry precipitation was forecast to build Saturday night, particularly in the state's northeast where more moisture will be available.
Forecasters say snow and sleet are likely before 9 p.m. in the northeast, followed by a chance of snow between 9 p.m. and midnight.
A cold front swept into the state Saturday and is forecast to drop temperatures into the 20s Saturday night.
In Tulsa, several accidents have been reported on several roadways prompting Tulsa police to enact Operation Slick Streets. When Slick Streets is in effect, police will not respond to non-injury accidents.
Officials with the City of Tulsa said trucks are sanding and salting bridges and overpasses.
"If they see drivers out when we start spreading, which we are at this time, around the bridges, they just need to slow down and stay back and let the operators do what they need to take care of on the roads," said Leon Kragel, operations manager for the street maintenance department.
The City of Tulsa has 30 trucks salting roads Saturday night and if the precipitation continues, they're prepared to work 16 hour shifts.
Kenna Mitchell, ODOT spokesperson, said they are also monitoring bridges and overpasses. She said ODOT has 60 team members out on county roads Saturday night operating 40 sand and salt trucks. Mitchell says ODOT crews will be out even after the storm passes.
"The thing about our work is that it's not done once the storm's over because there's always a potential for re-freezing the next night, so really we're out even after the storm finishes," she said.
The Oklahoma Highway Patrol is reporting heavy snow and sleet resulting in slick and hazardous roads in Kay, Noble and Osage counties.
Avant House of Prayer, Faith Temple Jesus Name Church, Cornerstone Baptist Church in Chouteau and First United Methodist Church in Claremore are also closed Sunday due to inclement weather.